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Fluid resuscitation is an integral part of critical care for burn injury patients where the necessary infusion rate is determined based on patient’s urinary output (UO). Motivated by an increasing interest in model-based development and in silico testing of automated burn resuscitation algorithms, we are investigating mathematical modeling of hemodynamic responses to burn injury and resuscitation. The model consists of 3 main components: (1) multi-compartmental volume kinetics including vascular and interstitial fluids and the associated flow interactions, (2) burn-induced hemodynamic perturbation including alterations in tissue permeability and compliance as well as denaturation with protein release, and (3) renal regulatory function including glomerular filtration rate as a function of intravascular volume state and reabsorption function representing the UO dependence on vasopressin. Preliminary evaluation of the initial model with data collected from animals show that the model can reproduce general trend of hemodynamic responses anticipated from burn injury and resuscitation.